Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p221 | (1) | WCRB2014

Meiotic and post-meiotic germ cells up-regulate blood–testis barrier function

Olcorn Justine Samantha , Rainczuk Katarzyna Eliza , Foo Caroline , Haverfield Jenna T , Stanton Peter G

Introduction: The blood–testis barrier (BTB) remains semi-permeable to tracers of increasing molecular weight in an adult rat model of spermatogenic re-initiation. Complete closure of the BTB occurred when steps 2–7 round spermatids re-appeared in the epithelium, and coincided with the localisation of a new tight junction (TJ) protein claudin-12 (Cldn12) at the BTB. We hypothesise that meiotic and/or post-meiotic germ cells up-regulate Sertoli cell TJs, and aim to de...